Route 01
Gastric (standard edibles)
- Onset
- 30 – 90 min
- Peak
- 90 – 180 min
- Duration
- 4 – 8 hrs
- Receptor potency
- 4 – 7× delta-9-THC at CB1
- Primary metabolite
- 11-hydroxy-THC (liver-converted)
- Examples
- Gummies, chocolates, brownies, capsules
Leafology Cannabis Company is a New York State-licensed adult-use cannabis dispensary at 244 Main Street, Suite 1, White Plains, NY 10601. This page is the edibles dosing guide our certified Cannabis Ganjier walks every first-time customer through at the counter — including the 2.5 / 90 / 2.5 protocol, the six-tier dose ladder, the 11-hydroxy-THC pharmacology, and the adverse-reaction playbook.
Dosing Guide
Start with 2.5 mg. Wait 90 minutes. Climb 2.5 mg at a time. The 2.5 / 90 / 2.5 protocol our Cannabis Ganjier walks every new customer through at the counter — calibrated against twelve months of live customer outcomes at 244 Main Street, White Plains.
mg · the first-dose floor
Leafology Cannabis Company is a New York State-licensed adult-use cannabis dispensary at 244 Main Street, Suite 1, White Plains, NY 10601. This guide is the operating manual our Cannabis Ganjier and senior budtenders run every new edibles customer through at the counter. New York's adult-use serving limit is 10 mg of THC per piece; most new consumers should start at 2.5 mg, wait 90 minutes, and only redose if the experience is comfortable. Edibles are the most dose-sensitive cannabis format on the market — a careful first session sets up every session after it. Below: the six-tier dose ladder, the absorption timeline, the metabolic pathway that makes edibles hit four to seven times harder than the equivalent smoked dose, the variables that change one person's response from another's, an adverse-reaction playbook, and the product picks our floor staff recommend by use-case.
Section 01 — The Ladder
Overestimating tolerance is the single most common reason a session goes sideways. Daily smokers routinely walk into the store and ask for 20 mg gummies on a first edible experience — and routinely call us at hour two from the couch, half-paralyzed. Smoking tolerance does not translate to edible tolerance one-to-one. Start at the tier below where you think you should be. You can always take another.
Tier 01
1
mg · THC
First-timers · seniors · daytime
Below psychoactive threshold for most adults. Mood and mild relaxation only. Stack 2 × 2.5 mg through the day for sustained calm with zero head-high.
Subjective feel
Subtle mood lift, no impairment, function-grade
Tier 02
2.5
mg · THC
Social · low tolerance · post-tolerance-break
New York's single-serving cap is 10 mg. A 5 mg portion is half a standard NY gummy — the canonical first-real-experience dose. Eat with light food; expect 30-90 minute onset.
Subjective feel
Light body warmth, social ease, mild euphoria
Tier 03
5
mg · THC
Casual consumer · weekly users · evening
One full NY serving. Sweet spot for weekly edible consumers. Plan a 4-6 hour window with no commitments — do not dose this and drive, ever.
Subjective feel
Noticeable body and head, conversational, content
Tier 04
10
mg · THC
Regular consumer · evening · couch session
Two NY servings. Tolerance-building dose. Expect 6-8 hour total experience. Most newcomers should NOT start here regardless of cannabis smoking history — eating THC is a different drug than smoking it.
Subjective feel
Heavy body, time dilation, deep relaxation, hungry
Tier 05
20
mg · THC
High tolerance · sleep · medical
Bedtime dose for high-tolerance consumers and patients on long-term medical regimens. Reserve for set-aside sessions. Plan zero responsibilities for 8 hours and the morning after.
Subjective feel
Sedating, deeply analgesic, impaired motor function
Tier 06
50
mg · THC
High-tolerance adult medical regimen · severe insomnia
Far beyond recreational territory. This range belongs to adult patients on long-term cannabinoid regimens working under a physician — not weekend consumers chasing intensity. Almost no first-timer should ever reach this tier; tolerance built over months is the only safe path here.
Subjective feel
Heavily sedating, full body lock, dissociative
Section 02 — Protocol
Three numbers, one operating system. Memorize them and edibles will never go sideways again.
Adapted from Dr. Sue Sisley's clinical microdose protocol and field-tested across 12 months of Leafology customer outcomes.
Typically a quarter of a 10 mg scored gummy, or one piece of a 2 - 2.5 mg micro-dose product. Take with a small amount of fat (peanut butter, cheese, whole-milk yogurt) — fat supports cannabinoid absorption and smooths the onset curve.
Set a timer. Do not redose. The most common edible-emergency call our budtenders take is from a customer who took a second piece at the 30-minute mark because 'it wasn't working.' It was working. Onset just hadn't completed.
Wait another 60 minutes. Re-evaluate. Most first-timers find their landing dose between 2.5 and 7.5 mg total. Some will be comfortable at 10 — the goal is not to maximize, it is to discover.
Note the dose, product, brand, time, food intake, and how you felt at 30 / 60 / 90 / 120 / 240 minutes. Your tolerance is data. Three sessions of notes save you a decade of guesswork.
Section 03 — Absorption
The same milligram of THC behaves differently depending on how it enters the body. Gastric (eaten), sublingual (under-tongue), and inhaled all engage CB1 receptors but with dramatically different onset, peak, duration, and metabolite profiles. Eating 10 mg is not the same drug as smoking 10 mg.
Route 01
Route 02
Route 03
Section 04 — Timeline
A standard gastric edible follows a predictable arc — first 90 minutes the liver is still working, the peak lands between hours 1.5 and 3, then four to six hours of taper. Sublingual and nano-emulsified products front-load the curve: faster onset, shorter peak, shorter tail.
0 – 15 min
Pre-onset
Edible enters stomach. Nothing felt. Sublingual products may begin onset here.
15 – 30 min
First-pass start
Liver begins converting delta-9-THC into 11-hydroxy-THC. Faintest signal possible.
30 – 60 min
Climb
Effects build noticeably. Body warmth, mood lift. Wave-like — small dips and surges normal.
60 – 90 min
Plateau approach
Most consumers reach the peak by minute 90. THIS is the redose checkpoint — never before.
90 – 180 min
Peak
Maximum effect. Strongest body sensation, head-change, time dilation. Lasts 1-3 hours.
3 – 6 hrs
Descent
Effects taper. Lingering relaxation, hunger, possible drowsiness.
6 – 8 hrs
Tail
Residual mellow. Light cognitive slowing. Most people sleep through this phase.
8 – 12 hrs
Hangover (rare)
Some consumers, especially at 20+ mg, feel mild grogginess until well-hydrated coffee + breakfast.
Section 05 — Variables
Body composition, recent food, sleep, age, and which CYP2C9 enzyme variant your liver expresses all bend the curve. Two adults of the same weight can have meaningfully different responses to the same 10 mg piece. Calibrate to yourself, not to the package.
Slows onset, smooths peak, extends duration. Heavy meals can push first-feel out to 2 hrs.
THC is fat-soluble. Higher body fat = slower clearance, longer-lasting peak. Lean consumers feel faster onset and shorter tail.
Faster basal metabolism = faster onset, shorter duration. Endurance athletes and naturally lean consumers often dose-up to feel the same effect.
10-20% of population has reduced CYP2C9 activity. They feel edibles dramatically harder than the same milligram dose in someone with normal expression.
Daily smokers tolerate higher edible doses but the EDIBLE high feels qualitatively different — heavier body, more sedating. Smoking tolerance ≠ edible tolerance 1:1.
Sleep debt and dehydration both amplify perceived intensity and the next-day fog. Hydrate before, during, after.
Anxiety-prone consumers report more THC-induced anxiety in stressful environments. Same dose, same body, calm room = pleasant; chaotic room = paranoid.
Adults 65+ generally need 50% less THC for the same effect. Start at 1-2 mg, climb in 1 mg increments. Liver function declines with age, slowing 11-OH-THC clearance.
Section 06 — If You Take Too Much
There is no documented case of fatal cannabis overdose in the medical literature. The body cannot achieve a lethal serum cannabinoid level via any normal consumption route. What you can do is have an extremely uncomfortable peak — racing heart, anxiety, nausea, time dilation, paranoia. It always passes. Here is the playbook our budtenders walk customers through on phone calls every weekend.
Pick a safe, dim, familiar room. Phone within reach. Tell at least one person you trust.
Hydration helps. Chugging water on a panicked stomach causes nausea. Sip every few minutes.
Bread, crackers, plain rice. Slows further absorption from anything still in your stomach.
5 - 20 mg sublingual CBD blunts THC intensity by competing at the CB1 receptor. Most adults feel relief within 30 minutes.
Two or three cracked peppercorns. The beta-caryophyllene terpene is a CB2 agonist and reliably reduces THC-induced anxiety in 10-15 minutes.
Limonene terpene calms the nervous system fast. Citrus essential oil works too if peeling lemon is not realistic.
Comedy show, a familiar movie, music, a hot shower. Avoid mirrors, news, social media, anything that engages anxiety loops.
Most edible peaks self-resolve through sleep. The body wakes up calmer; the residual is mild grogginess at worst.
Medical emergency signals: chest pain that does not pass, vomiting that does not stop, fainting, severe dehydration, hallucinations that persist past four hours. Call NYS Poison Control: 1-800-222-1222. If the consumer is under 21, under 100 lbs, or has cardiac history, call sooner rather than later.
Section 07 — Picks by use-case
First-timer · daytime
2 – 2.5 mg
Below psychoactive threshold. Function-safe. Build the receptor map.
Shop on the menuSocial evening · low tolerance
5 mg
One scored 10 mg piece cut in half. The canonical 'one drink' edible equivalent.
Shop on the menuFast-onset · party
5 – 10 mg
10-25 min onset vs the standard 60-90 min. Better dose control, shorter duration.
Shop on the menuSleep · high tolerance
10 – 25 mg
CBN is naturally sedating. The combo lands harder for sleep than pure THC at equal dose.
Shop on the menuSustained body relief
10 – 20 mg, twice daily
Sublingual onset for fast feedback; balanced cannabinoid ratio softens THC's head-change while extending the body component.
Shop on the menuAnxiety-cautious
2.5 mg + 5 mg CBD
CBD buffers THC-induced anxiety without killing the body feel. Best entry point for cannabis-anxious adults.
Shop on the menuSection 08 — Key answers
Live menu of every gummy, chocolate, mint, beverage, and tincture on the Leafology shelf right now — 2 mg micro-dose to 100 mg stacks, fast-onset nano-emulsified included.
ExploreCannabis storage protocol — the four enemies, the 59-63% RH range, mason vs Cvault, and why fridge and freezer ruin trichomes.
ExploreEarn on every edible purchase. Free, no tier-resets, redeems at the register on pickup and delivery.
Explore60+ answered questions across products, dosing, NY law, delivery, pickup, and rewards.
Explore2 mg micro-dose to 100 mg stacks. NY-licensed, lab-tested, on the Leafology shelf right now.