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Leafology

Leafology Cannabis Company is a New York State-licensed adult-use cannabis dispensary at 244 Main Street, Suite 1, White Plains, NY 10601. This page is the edibles dosing guide our certified Cannabis Ganjier walks every first-time customer through at the counter — including the 2.5 / 90 / 2.5 protocol, the six-tier dose ladder, the 11-hydroxy-THC pharmacology, and the adverse-reaction playbook.

Dosing Guide

The dosing system we teach every first-time edibles customer.

Start with 2.5 mg. Wait 90 minutes. Climb 2.5 mg at a time. The 2.5 / 90 / 2.5 protocol our Cannabis Ganjier walks every new customer through at the counter — calibrated against twelve months of live customer outcomes at 244 Main Street, White Plains.

2.5 mg first dose·30–90 min onset·4–8 hrs duration·10 mg NY single-serving cap
2.5

mg · the first-dose floor

Leafology Cannabis Company is a New York State-licensed adult-use cannabis dispensary at 244 Main Street, Suite 1, White Plains, NY 10601. This guide is the operating manual our Cannabis Ganjier and senior budtenders run every new edibles customer through at the counter. New York's adult-use serving limit is 10 mg of THC per piece; most new consumers should start at 2.5 mg, wait 90 minutes, and only redose if the experience is comfortable. Edibles are the most dose-sensitive cannabis format on the market — a careful first session sets up every session after it. Below: the six-tier dose ladder, the absorption timeline, the metabolic pathway that makes edibles hit four to seven times harder than the equivalent smoked dose, the variables that change one person's response from another's, an adverse-reaction playbook, and the product picks our floor staff recommend by use-case.

Section 01 — The Ladder

Six tiers. Pick the row that matches your tolerance honestly.

Overestimating tolerance is the single most common reason a session goes sideways. Daily smokers routinely walk into the store and ask for 20 mg gummies on a first edible experience — and routinely call us at hour two from the couch, half-paralyzed. Smoking tolerance does not translate to edible tolerance one-to-one. Start at the tier below where you think you should be. You can always take another.

  1. Tier 01

    1

    mg · THC

    Micro-dose · 1 – 2.5 mg

    First-timers · seniors · daytime

    Below psychoactive threshold for most adults. Mood and mild relaxation only. Stack 2 × 2.5 mg through the day for sustained calm with zero head-high.

    Subjective feel

    Subtle mood lift, no impairment, function-grade

  2. Tier 02

    2.5

    mg · THC

    Low · 2.5 – 5 mg

    Social · low tolerance · post-tolerance-break

    New York's single-serving cap is 10 mg. A 5 mg portion is half a standard NY gummy — the canonical first-real-experience dose. Eat with light food; expect 30-90 minute onset.

    Subjective feel

    Light body warmth, social ease, mild euphoria

  3. Tier 03

    5

    mg · THC

    Standard · 5 – 10 mg

    Casual consumer · weekly users · evening

    One full NY serving. Sweet spot for weekly edible consumers. Plan a 4-6 hour window with no commitments — do not dose this and drive, ever.

    Subjective feel

    Noticeable body and head, conversational, content

  4. Tier 04

    10

    mg · THC

    Medium · 10 – 20 mg

    Regular consumer · evening · couch session

    Two NY servings. Tolerance-building dose. Expect 6-8 hour total experience. Most newcomers should NOT start here regardless of cannabis smoking history — eating THC is a different drug than smoking it.

    Subjective feel

    Heavy body, time dilation, deep relaxation, hungry

  5. Tier 05

    20

    mg · THC

    Strong · 20 – 50 mg

    High tolerance · sleep · medical

    Bedtime dose for high-tolerance consumers and patients on long-term medical regimens. Reserve for set-aside sessions. Plan zero responsibilities for 8 hours and the morning after.

    Subjective feel

    Sedating, deeply analgesic, impaired motor function

  6. Tier 06

    50

    mg · THC

    Heavy · 50 – 100 mg+

    High-tolerance adult medical regimen · severe insomnia

    Far beyond recreational territory. This range belongs to adult patients on long-term cannabinoid regimens working under a physician — not weekend consumers chasing intensity. Almost no first-timer should ever reach this tier; tolerance built over months is the only safe path here.

    Subjective feel

    Heavily sedating, full body lock, dissociative

Section 02 — Protocol

2.5 / 90 / 2.5

Three numbers, one operating system. Memorize them and edibles will never go sideways again.

Adapted from Dr. Sue Sisley's clinical microdose protocol and field-tested across 12 months of Leafology customer outcomes.

  1. 01

    Take 2.5 mg of THC

    Typically a quarter of a 10 mg scored gummy, or one piece of a 2 - 2.5 mg micro-dose product. Take with a small amount of fat (peanut butter, cheese, whole-milk yogurt) — fat supports cannabinoid absorption and smooths the onset curve.

  2. 02

    Wait 90 minutes — full stop

    Set a timer. Do not redose. The most common edible-emergency call our budtenders take is from a customer who took a second piece at the 30-minute mark because 'it wasn't working.' It was working. Onset just hadn't completed.

  3. 03

    If comfortable at 90 minutes, add 2.5 mg

    Wait another 60 minutes. Re-evaluate. Most first-timers find their landing dose between 2.5 and 7.5 mg total. Some will be comfortable at 10 — the goal is not to maximize, it is to discover.

  4. 04

    Log it

    Note the dose, product, brand, time, food intake, and how you felt at 30 / 60 / 90 / 120 / 240 minutes. Your tolerance is data. Three sessions of notes save you a decade of guesswork.

Section 03 — Absorption

Three routes. Three different drugs, pharmacologically speaking.

The same milligram of THC behaves differently depending on how it enters the body. Gastric (eaten), sublingual (under-tongue), and inhaled all engage CB1 receptors but with dramatically different onset, peak, duration, and metabolite profiles. Eating 10 mg is not the same drug as smoking 10 mg.

Route 01

Gastric (standard edibles)

Onset
30 – 90 min
Peak
90 – 180 min
Duration
4 – 8 hrs
Receptor potency
4 – 7× delta-9-THC at CB1
Primary metabolite
11-hydroxy-THC (liver-converted)
Examples
Gummies, chocolates, brownies, capsules

Route 02

Sublingual (under-tongue)

Onset
10 – 25 min
Peak
45 – 90 min
Duration
2 – 4 hrs
Receptor potency
1× delta-9-THC at CB1
Primary metabolite
Delta-9-THC (bypasses liver)
Examples
Tinctures, dissolvable mints, fast-acting gummies with nano-emulsified THC

Route 03

Inhaled (comparison)

Onset
Seconds
Peak
10 – 15 min
Duration
1 – 3 hrs
Receptor potency
1× delta-9-THC at CB1
Primary metabolite
Delta-9-THC (lung absorption)
Examples
Flower, pre-rolls, vapes (this guide does not apply to inhaled cannabis)

Section 04 — Timeline

Hour by hour. What is actually happening from minute zero.

A standard gastric edible follows a predictable arc — first 90 minutes the liver is still working, the peak lands between hours 1.5 and 3, then four to six hours of taper. Sublingual and nano-emulsified products front-load the curve: faster onset, shorter peak, shorter tail.

  1. 0 – 15 min

    Pre-onset

    Edible enters stomach. Nothing felt. Sublingual products may begin onset here.

  2. 15 – 30 min

    First-pass start

    Liver begins converting delta-9-THC into 11-hydroxy-THC. Faintest signal possible.

  3. 30 – 60 min

    Climb

    Effects build noticeably. Body warmth, mood lift. Wave-like — small dips and surges normal.

  4. 60 – 90 min

    Plateau approach

    Most consumers reach the peak by minute 90. THIS is the redose checkpoint — never before.

  5. 90 – 180 min

    Peak

    Maximum effect. Strongest body sensation, head-change, time dilation. Lasts 1-3 hours.

  6. 3 – 6 hrs

    Descent

    Effects taper. Lingering relaxation, hunger, possible drowsiness.

  7. 6 – 8 hrs

    Tail

    Residual mellow. Light cognitive slowing. Most people sleep through this phase.

  8. 8 – 12 hrs

    Hangover (rare)

    Some consumers, especially at 20+ mg, feel mild grogginess until well-hydrated coffee + breakfast.

Section 05 — Variables

Eight variables. Same milligrams, different person, different ride.

Body composition, recent food, sleep, age, and which CYP2C9 enzyme variant your liver expresses all bend the curve. Two adults of the same weight can have meaningfully different responses to the same 10 mg piece. Calibrate to yourself, not to the package.

V01

Food in stomach

Slows onset, smooths peak, extends duration. Heavy meals can push first-feel out to 2 hrs.

V02

Body composition

THC is fat-soluble. Higher body fat = slower clearance, longer-lasting peak. Lean consumers feel faster onset and shorter tail.

V03

Metabolic rate

Faster basal metabolism = faster onset, shorter duration. Endurance athletes and naturally lean consumers often dose-up to feel the same effect.

V04

Liver enzyme expression (CYP2C9)

10-20% of population has reduced CYP2C9 activity. They feel edibles dramatically harder than the same milligram dose in someone with normal expression.

V05

Recent cannabis use

Daily smokers tolerate higher edible doses but the EDIBLE high feels qualitatively different — heavier body, more sedating. Smoking tolerance ≠ edible tolerance 1:1.

V06

Sleep and hydration

Sleep debt and dehydration both amplify perceived intensity and the next-day fog. Hydrate before, during, after.

V07

Mindset and setting

Anxiety-prone consumers report more THC-induced anxiety in stressful environments. Same dose, same body, calm room = pleasant; chaotic room = paranoid.

V08

Age

Adults 65+ generally need 50% less THC for the same effect. Start at 1-2 mg, climb in 1 mg increments. Liver function declines with age, slowing 11-OH-THC clearance.

Section 06 — If You Take Too Much

You cannot fatally overdose. You can have a very rough couple of hours.

There is no documented case of fatal cannabis overdose in the medical literature. The body cannot achieve a lethal serum cannabinoid level via any normal consumption route. What you can do is have an extremely uncomfortable peak — racing heart, anxiety, nausea, time dilation, paranoia. It always passes. Here is the playbook our budtenders walk customers through on phone calls every weekend.

  1. 01

    Sit or lie down

    Pick a safe, dim, familiar room. Phone within reach. Tell at least one person you trust.

  2. 02

    Sip water — do not chug

    Hydration helps. Chugging water on a panicked stomach causes nausea. Sip every few minutes.

  3. 03

    Eat something starchy

    Bread, crackers, plain rice. Slows further absorption from anything still in your stomach.

  4. 04

    Take CBD if available

    5 - 20 mg sublingual CBD blunts THC intensity by competing at the CB1 receptor. Most adults feel relief within 30 minutes.

  5. 05

    Chew black peppercorns

    Two or three cracked peppercorns. The beta-caryophyllene terpene is a CB2 agonist and reliably reduces THC-induced anxiety in 10-15 minutes.

  6. 06

    Smell crushed lemon zest

    Limonene terpene calms the nervous system fast. Citrus essential oil works too if peeling lemon is not realistic.

  7. 07

    Distract — do not spiral

    Comedy show, a familiar movie, music, a hot shower. Avoid mirrors, news, social media, anything that engages anxiety loops.

  8. 08

    Sleep if possible

    Most edible peaks self-resolve through sleep. The body wakes up calmer; the residual is mild grogginess at worst.

Medical emergency signals: chest pain that does not pass, vomiting that does not stop, fainting, severe dehydration, hallucinations that persist past four hours. Call NYS Poison Control: 1-800-222-1222. If the consumer is under 21, under 100 lbs, or has cardiac history, call sooner rather than later.

Section 08 — Key answers

Quick answers to the three questions our counter staff hear daily.

What is 11-hydroxy-THC?

11-hydroxy-THC is the metabolite the liver creates when it breaks down ingested delta-9-THC. It binds the CB1 receptor four to seven times more strongly than delta-9 itself, which is why edibles feel disproportionately strong compared to the same milligram dose smoked. It is also why edibles last four to eight hours instead of the 90-minute peak of inhaled cannabis.

Why does the same edible feel different on different days?

Three variables. (1) What and when you last ate — fat and a partial stomach slow absorption and smooth the curve. (2) Hydration and sleep — both modulate liver enzyme expression. (3) Baseline mood and setting. Same product, same dose, same body — different day, different experience. This is normal. Track it and the pattern is visible by session three.

Are fast-onset / nano-emulsified edibles worth the premium?

Yes if you want better dose control, no if you want longest-lasting effect. Nano-emulsified products onset in 10-25 minutes (vs the standard 60-90) by partially absorbing sublingually before they reach the stomach. The benefit: you find out faster whether you under-dosed and can correct without waiting an hour and a half. The trade-off: shorter total duration (~2-4 hrs vs 4-8 hrs) because less of the dose routes through the liver into the heavier-hitting 11-OH-THC pathway.
  1. How many mg of THC should a first-time edible user take?

    Start with 2.5 mg of THC. Wait a full 90 minutes before deciding whether to take more. New York's adult-use serving limit is 10 mg per piece, so most legal gummies and chocolates from Leafology are scored or pre-portioned at 5 or 10 mg — a 2.5 mg first dose usually means cutting a 10 mg piece into quarters or buying a 2 - 2.5 mg micro-dose product specifically. The dose can feel like nothing the first time; that is the correct outcome — it confirms your baseline before you climb.
  2. How long does an edible take to kick in?

    Most THC edibles begin onset in 30 to 90 minutes when taken on a lightly-fed stomach. Onset can stretch to 2 hours after a heavy meal. Sublingual products (mints, tinctures, fast-acting gummies with nano-emulsified THC) onset faster — typically 10 to 25 minutes — because they partially absorb through the mucous membrane and bypass first-pass liver metabolism. Effects last 4 to 8 hours total depending on dose, body composition, metabolism, and meal context.
  3. What is 11-hydroxy-THC and why do edibles feel so much stronger?

    11-hydroxy-THC is the metabolite the liver creates when it breaks down ingested delta-9-THC. It binds to the CB1 receptor four to seven times more strongly than delta-9-THC itself, which is why a 10 mg edible feels disproportionately stronger than a 10 mg vape puff. The same liver pass also slows release of cannabinoids into the bloodstream, stretching the experience to 4-8 hours instead of the 1-3 hour curve of inhaled cannabis. This is the primary reason edibles are the most dose-sensitive cannabis format on the market.
  4. What do I do if I take too much THC?

    You cannot fatally overdose on cannabis — there is no documented case in medical literature. What you can do is have a very uncomfortable couple of hours. The protocol: sit or lie down somewhere safe and dark, hydrate with sips of water, eat starchy food (bread, crackers, rice) to slow further absorption, take 5-20 mg of CBD sublingually if available — CBD blunts THC intensity. Black peppercorns chewed and lemon zest sniffed both contain terpenes (beta-caryophyllene and limonene) that reduce THC anxiety. Effects always pass; peak fades in 2-3 hours. If symptoms feel medically dangerous (chest pain, vomiting that does not stop, fainting), call NYS Poison Control at 1-800-222-1222.
  5. Why didn't my edible work the first time?

    Two common reasons. (1) You didn't wait long enough — edibles take up to 2 hours to onset, and many people redose at the 45-minute mark before the first piece has hit. (2) Your liver's first-pass metabolism is slow or atypical, which delays conversion of delta-9-THC into 11-hydroxy-THC. Some new consumers feel almost nothing on the first one or two attempts; by the third session, the body's enzyme expression has adjusted and a 5 mg dose hits as expected. Persist through the first three sessions before judging dose response.
  6. How is an edible high different from smoking?

    Smoked or vaporized THC reaches the bloodstream through the lungs in under a minute and peaks at 10-15 minutes, lasting 1-3 hours. Edibles route through the digestive tract to the liver, which converts THC into 11-hydroxy-THC — a different metabolite, 4-7× more potent at CB1, lasting 4-8 hours. Subjectively: smoked highs feel head-forward, light, energetic for the first 20 minutes. Edible highs feel body-heavy, sedating, more dose-sensitive, and qualitatively closer to a deep relaxant than a stimulant.
  7. Can I mix THC edibles with alcohol?

    Don't. Alcohol amplifies THC absorption and the combined depressant effect is unpredictable — even experienced consumers get blindsided. The metabolic pathways overlap (both engage liver enzymes), and the additive sedation can cross safety lines individually neither would. Pick one or the other, especially on the first ten or so edible sessions while you're still calibrating dose. If you must mix, eat first, then drink, and cap THC at 2.5-5 mg.
  8. Does Leafology sell 2 mg micro-dose edibles?

    Yes. Several brands on the Leafology shelf produce 2 mg and 2.5 mg micro-dose gummies and mints specifically for first-timers, daytime use, and senior consumers. Ask any budtender or the Cannabis Ganjier at the counter — they will walk you to the exact SKU based on your goal, baseline tolerance, and onset preference (gastric or sublingual). Same-day delivery to all 48 Westchester towns; pickup ready in ~15 minutes at 244 Main Street.
  9. How long do edibles stay in your system?

    Active effect: 4 to 8 hours. Drug-test detection: 3 to 30 days, depending on body fat, frequency, and dose. THC's metabolite THC-COOH is fat-soluble and stores in adipose tissue, then re-releases as fat metabolizes. A single 10 mg edible may show on a urine test for 2-5 days in an occasional consumer and up to 30 days in a daily heavy consumer. Hair-follicle tests detect up to 90 days. Blood tests detect only 12-24 hours after a single dose.
  10. What is the strongest legal edible in New York?

    New York's Office of Cannabis Management caps a single serving of an edible at 10 mg of THC and a single package at 100 mg total. So 100 mg in one tin (10 × 10 mg pieces, individually scored) is the legal maximum for adult-use. Certified New York medical-cannabis patients may have access to higher-strength formats via the state's medical program — ask a budtender or the Cannabis Ganjier in-store and they will walk you through current eligibility and program-specific products available at Leafology.
  11. Can I take edibles every day?

    Yes, with tolerance and lifestyle awareness. Daily 2-5 mg micro-doses for daytime mood support are well-tolerated by most adults. Daily 10-20 mg evening doses for sleep build tolerance fast — you'll need 30-40 mg within 3-4 weeks to feel the original effect. A 5-7 day tolerance break every 6-8 weeks resets receptor sensitivity. There is no evidence of serious long-term harm from moderate daily cannabis use; there is real evidence of dependence, dose escalation, and motivation impact in heavy daily users.
  12. Why do I feel different on the same edible from one day to the next?

    Three variables. (1) What and when you last ate — fat and a partial stomach slow absorption and smooth the curve. (2) Sleep and hydration — both modulate liver enzyme expression and perceived intensity. (3) Baseline mood and setting — same body, same dose, different mental state produces measurably different experiences. This is normal pharmacology, not product inconsistency. Track these three variables over five sessions and the pattern emerges.
  13. Is CBD edible different from THC edible dosing?

    Yes. CBD does not produce psychoactive effects at standard doses. Most consumers report a useful CBD floor around 15-25 mg sublingually or 25-50 mg orally. CBD has a much wider therapeutic window — 100 mg + is well-tolerated by most adults — but bioavailability is lower than THC, so onset is slower and total cannabinoid in the bloodstream is smaller per milligram dosed. Combining 1:1 or 2:1 CBD:THC ratios is the most common medical approach for pain and anxiety because CBD softens THC's psychoactive edge while preserving the analgesic and anti-inflammatory effects.

Shop edibles — pickup or same-day delivery.

2 mg micro-dose to 100 mg stacks. NY-licensed, lab-tested, on the Leafology shelf right now.

244 Main Street, Suite 1, White Plains, NY 10601
Mon-Sat 8 AM - 10 PM | Sun 8 AM - 8 PM
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